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Sw-5 , originally introgressed in the cultivar Stevens, is currently the primary source of TSWV resistance in commercial tomato varieties worldwide 50,51

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However, recurrence and treatment non-responsiveness remain critical issues, necessitating further in-depth research

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Both preventative studies showing reducing UV-induced pigmentation and therapeutic trials demonstrating improvement in melasma and age-associated hyperpigmentation provide evidence for clinical relevance of topical antioxidants [55, 56, 66,67,68]

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