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14 The APC protein is located in the cytoplasm, and mutations in this protein cause Wnt pathway activation in human cancers

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However, increasing structural and compositional complexity introduces challenges related to long-term safety evaluation, regulatory approval, and reproducible manufacturing, highlighting the need for rigorous validation frameworks [183]

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doi:10.1007/s11684-021-0871-4 Alomari MA, Khabour OF, Gharaibeh MY, Qhatan RA

doi: 10.4254/wjh.v6.i3.144