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In a study using the gold-standard experimental model of polymicrobial sepsis, the cecal ligation and puncture (245), metabolic analysis of plasma and urine identified 14 plasma and 11 urine metabolites related to central carbon and choline metabolism (including choline, betaine, methylamine, and creatinine)

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Here, we discuss the relationship and related pathophysiologic mechanisms between TMAO and AS, as well as the potential therapeutic strategies that target these pathophysiologic mechanisms