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Currently, there is no practical way to measure individual NNMT activity to predict response

So the practical takeaway is not oral is better or SC is better. It is: pick one route, follow the documented per-dose figure for the vial you have, and keep the route constant so that whatever you observe is not confounded by a mid-stream route change

That is the entire basis for the you can take it orally framing you will see repeated online

Social isolation affects the development of obesity and type 2 diabetes in mice (in Eng)

The Neelakantan 2018 paper showed strong oral absorption in cell uptake (Caco-2) assays, which is why most research community use is by mouth instead of by injection

Second, the doses are small because the target is a high-affinity intracellular enzyme, not a receptor that needs saturating with milligrams of drug