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Instead AP-1 appears to be essential for TBH-mediated induction of the rat GCLC gene (Yang et al., 2002)

[DOI] [PMC free article] [PubMed] [Google Scholar] 264.Prasad A., Rathi D., Sedlarova M., Manoharan R.R., Prudkova E., Pospisil P

[DOI] [PubMed] [Google Scholar] 124.Li C., Deng X., Xie X., Liu Y., Friedmann Angeli J.P., Lai L

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However, PGE2 is known to play a dual role, as it can both suppress the immune response against M.tb and protect the host from excessive inflammation, suggesting that NSAIDs should be exercised with caution for TB treatment [128]

It is recognized as a neurodegenerative disease typically occurring later in life, with a significant genetic component that manifests in susceptible individuals exposed to epigenetic changes