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Due to the distinct position of the conjugated N-terminal lipid between Cagri-CTR and Cagri-AMY 1 R, we also determined a structure of CTR-Gs in complex with an analogue of Cagri that lacked the lipid modification (CagriBB) to interrogate the contribution of the acylation to the conformation of Cagri-CTR complex

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Lastly, investigating combination therapies that integrate ferroptosis inhibitors with other therapeutic strategies, such as antioxidants or anti-inflammatory agents, may provide synergistic benefits and improve treatment outcomes