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An increased proportion of PUFAs in normal diet also induces oxidative stress (increased malondialdehyde [MDA]), reduces cellular defense against oxidative stress (metallothionein) in the liver, and promotes oxidative degradation of DNA (elevated 8-hydroxy-2-deoxyguanosine levels serum) in a content-dependent manner despite increased fat oxidation and decreased fat synthesis [80]
Cells 8 , 1417 (2019)
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