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Evidence suggests that acetoacetate inhibits glutamate release and another mechanism by which KD reduces glutamate is that Cl-activates vesicular glutamate transporters, while increased ketone bodies, especially acetoacetate, inhibit vesicular glutamate transporters by competing with Cl , thereby inhibiting glutamate release (101) (Figure 2B)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 252.Yang D.J., Moh S.H., Choi Y.H., Kim K.W

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