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Never inject into areas without sufficient subcutaneous fat, such as very lean abdominal areas or over bone

The compound progressed through Phase 2 trials under ConjuChem in the mid-2000s for indications including HIV-associated lipodystrophy, but did not advance to a marketed therapeutic

However, in mice that received peripheral administration of a high dose of fluorescein-ghrelin, the fluorescein signal was observed not only in the ARC and ME but also in the AP and paraventricular nucleus (PVN), suggesting that circulating ghrelin can traverse fenestrated capillaries and reach certain CVOs (55)

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Osuka S, Zhu D, Zhang Z, Li C, Stackhouse CT, Sampetrean O, Olson JJ, Gillespie GY, Saya H, Willey CD, et al

J., Kalivas P