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Effects on cellular NAD+ and SAM pools in vitro

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Notably, studies have shown that knocking down NNMT in adipose tissues and livers of mice fed a high-fat diet resulted in decreased serum TG and FFA levels (Zhu et al., 2016)

Weight Regulation In animal studies, AOD-9604 reduced body fat mass and improved metabolic parameters. Early human trials showed limited direct weight loss, but trends toward improved lipid metabolism. Key takeaway: May influence weight management indirectly by altering fat metabolism

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