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Future studies should prioritize large-scale, single-strain multicenter RCTs to validate long-term efficacy and safety, standardize detection protocols and experimental designs to reduce heterogeneity, and deepen mechanistic exploration of Clostridium /metabolitetarget cell interactions

Because hypoglycemic events may be difficult to recognize in some elderly patients, antidiabetic agent regimens should be carefully managed to obviate an increased risk of severe hypoglycemia

doi: 10.1021/bi00080a021

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