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Blood System: Under the stimulation of chronic hypoxia, the expression of hypoxia inducible factors is activated, thereby stimulating the kidneys and liver to secrete a large amount of EPO ( Renal System: During acute hypoxia, activation of the adrenergic system leads to tachycardia

Suckfuell et al., 2014) and a Phase I trial for systemic treatment of solid tumors(Warso et al., 2013), together showing there is precedence for DRI peptides in clinical therapy

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