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DNA damage leads to genomic instability and induces functional mutations in oncogenes or tumor-suppressor genes, which are a causative factor for tumorigenesis 81

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NPT088 treated Thy1-H-syn mice showed increased tyrosine hydroxylase levels concomitant with a significant reduction in proteinase K-resistant -syn (Fisher et al., Molecular tweezers have also been shown to be strong dissociative and anti-aggregation agents (Sinha et al., in vitro inhibiting -syn aggregation across multiple studies (Sinha et al., in vitro and has also been shown to reduce -syn proteasomal inhibition in zebrafish (Prabhudesai et al., Immunotherapy is another promising strategy for the reduction of -syn aggregates that is currently in clinical trials