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Nuclear signals are involved in resisting mechanical changes during cell migration and interfere with biochemical signals of malignant transformation [38]

[Retinal and trabecular degeneration in glaucoma: new insights into pathogenesis and treatment]

These interactions form a highly competitive and dynamic metabolic network where nutrient availability, mitochondrial function, and metabolite-mediated signaling pathways collectively orchestrate immune surveillance and tumor progression

Kelly PA, Bachelot A, Kedzia C, Hennighausen L, Ormandy CJ, Kopchick JJ, Binart N

It emphasizes their multi-target pharmacological actions across key pathological processes, including the restoration of skin barrier integrity, modulation of immune and chemokine dysregulation, itch signaling pathways, rebalancing of microbial homeostasis, modulation of programmed cell death pathways, and attenuation of oxidative stress and redox imbalance

doi: 10.1038/s41467-021-24859-2 17 AlborziniaHFlrezAFKrethSBrcknerLMYildizUGartlgruberMet al