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[DOI] [PMC free article] [PubMed] [Google Scholar] 90.Dykstra-Aiello C, et al

The resolution of the crystal structure for the glucocorticoid-binding site of the glucocorticoid receptor reveals pockets that could allow the design of novel corticosteroids

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By mapping regulatory variants that influence gene or protein expression levels, eQTL and pQTL analyses help to elucidate the functional mechanisms of cataract-associated loci identified through genome-wide association studies (GWAS), thereby facilitating the discovery of potential therapeutic targets (12, 13)

In other words, these oxidised proteins were not degraded by proteasome rapid enough to avoid apoptotic death resulting from the build up of these proteins

262 Despite 2-integrin expression being regulated at the transcriptional level, accepted dogma held that changes in 2-integrin expression relevant to leukocyte function occur almost exclusively after protein translation