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This combination therapy results in increased activation of CD8 + T cells and CD86 + dendritic cells in the spleen, leading to elevated levels of pro-inflammatory cytokines [206]
doi: 10.1503/cmaj.1040752
Dollet, L
Consequently, this imbalance contributes to a higher mutation rate in mitochondrial DNA (mtDNA) (Coskun and Busciglio 2012
A common variant in methionine synthase reductase combined with low cobalamin (vitamin B 12) increases risk for spina bifida
PDR-1, Parkin homologue in Caenorhabditis elegans
