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In our study, livers of macrophage-specific IRG1 knockout mice showed no changes in itaconate levels during fasting, while hepatocyte, endothelial, and neutrophil IRG1 knockouts exhibited increased itaconate levels in fasting compared to fed mice

10.1038/s41467-019-13896-7 Nat

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Regulatory Considerations: Depending on the nature and location of your research in 2026, different regulatory bodies might have specific guidelines regarding the administration of research compounds