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In the MPTP model of PD, treatment with OLT1177 can prevent the loss of motor function by inhibiting NLRP3, reducing -synuclein levels, modulating proinflammatory markers in the substantia nigra-striatum region, and protecting dopaminergic neurons from degeneration, thereby improving PD symptoms [167]

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In other words, the post-translational maturation appears to be hampered in the mutant SOD1 proteins, resulting in an increased propensity of SOD1 to misfold into oligomers and aggregates

I had a similar reaction to one of the monthly injections, but only that once