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The combination of exercise followed by sauna use has been shown to increase BDNF expression beyond what either intervention achieves alone

This review focuses on the comprehensive appraisal of two main processes associated with the development of CICI: neuroinflammation and oxidative stress, and proposes the endogenous cannabinoid system (ECS) as a new therapeutic target against CICI

Lin Y-C, Schneider F, Eberle KJ, Chiodi D, Nakamura H, Reisberg SH, et al

(2022b)

The clinical proof of concept comes from CagriSema, the combination of cagrilintide with semaglutide
