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Knock-out of GH or its receptor (GHR), both expressed in the mouse fetus, did not affect birth size, indicating that the Igf 1 gene is not under GH control during the fetal period

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Given that we have established selenoproteins such as GPx3 and SELENOP to be substantially reduced in those affected with disease using multiple applications and cohorts, perhaps a reduction in the ability to effectively manage oxidative damage is a leading factor for disease susceptibility and severity, when all other risk factors have been met, which are typically present even in those without konzo