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Studies on its cardiovascular effects in at-risk populations pointed to a lowered incidence of major adverse cardiovascular events (MACE), such as stroke and heart attack

In a different liraglutide (Saxenda) clinical trial, individuals who took the drug lost an average of 5.9% of their body weight over the course of 56 weeks, with a significant weight loss seen as early as week 12

GI symptoms (e.g., nausea/vomiting, diarrhea)

it functions through systemic hormone signaling rather than local gastric action

Complete obstructions usually require immediate surgery