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Elevated levels of plasma homocysteine in postmenopausal women in Burkina Faso

Start at the low end of the beginner tier and extend the observation period to three weeks instead of two before increasing

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This observation could reflect an inability to increase luminal hydration, owing to lack of claudin-2-mediated water transport, that synergized with colitis-associated epithelial proliferation, mucosal expansion and luminal narrowing to allow formation of luminal faecaliths and intestinal obstruction

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Typical weekly range: 2.515 mg once weekly (gradual 4week titration steps)