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Downregulation of CAV1 reduces the levels of GPX4 and FTH1, increases ROS and Fe 2+ concentrations, promotes ferroptosis, and reduces cancer cell migration and invasion, 171 suggesting that the regulatory pathways of CAV1 and ferroptosis may be potential targets for diagnosis and combination therapy strategies in patients with HNSCC

Arterioscler Thromb Vasc Biol 25: 13321340, 2005 [DOI] [PubMed] [Google Scholar] 55.Leopold JA, Zhang YY, Scribner AW, Stanton RC, Loscalzo J

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This suggests that sustained astrocytic glycolysis occurs in order to maintain the extracellular lactate pool to meet the energy requirements of neurons