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Description
Clinical pharmacokinetics of docetaxel

Blocking NNMT preserves the NAD+ precursor pool (1.2-1.6x increase in intracellular NAD+), increases SAM availability for epigenetic methylation, and activates SIRT1/SIRT3 signaling

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Intervention Study Comparing Blood NAD+ Concentrations with Liposomal and Non-Liposomal Nicotinamide Mononucleotide

Among all subgroups, baseline subcategories with body mass index (BMI) lower than 30 kg/m 2 , patients with type 1 diabetes, clinically relevant smokers, and angiotensin-converting-enzyme (ACE) inhibitor-treated subgroups showed mean improvement (more than 1 point) in NIS-LL in ALA-treated group after 4 years

PloS One (2019) 14:e0214295
