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Subsequent studies showed that Mc3r knockout mice exhibit increased adiposity without developing overt obesity and, in some cases, display hypophagia (20, 22)

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The risk of first onset atherosclerotic cardiovascular disease (ASCVD) in the highest baseline TMAO group of the elderly in the community increased by 21% (HR 1.21), and the risk of recurrence in ASCVD patients increased by 25% (HR 1.25), of which the association was stronger in patients with renal insufficiency (132)