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Autophagy deficiency exacerbates iron overload induced reactive oxygen species production and apoptotic cell death in skeletal muscle cells

Initially, B12 shots are usually administered 1-3 times per week

MEASUREMENTS AND RESULTS: The primary outcome is change in plasma p-tau181 concentration between baseline and following 180 days of treatment, which will be compared between the active and placebo group

Autophagy in neurodegenerative diseases: from mechanism to therapeutic approach

Cell viability assay Well-characterized and standardized human hepatoblastoma (HepG2) cells were obtained from Korea Cell Line Bank (Seoul, Korea)

Virology 279(2):371374 Gomez RM, Yep A, Schattner M, Berra MI (2003) Junin virus-induced astrocytosis is impaired by iNOS inhibition