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Excitatory neurons exhibit the earliest and most substantial mitochondrial impairments, including reduced oxidative phosphorylation, decreased ATP generation, and elevated production of ROS (Wang et al., 2009a

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We address this with a locally adapted MEGA-PRESS sequence incorporating interleaved unsuppressed water acquisitions, allowing concurrent assessment of behaviour, blood-oxygenation-level-dependent (BOLD) functional changes, Glutamate + Glutamine (Glx), and GABA, synchronised with a cognitive (flanker) task

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