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Of note, these TREM2 macrophages were in a hypermetabolic state, with increased expression of fructose-1,6-bisphosphatase 1 (FBP1) and other enzymes involved in metabolism

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In addition to the noted effects of ascorbate on neurotransmitters, ascorbate also has been shown to be involved in neuropeptide amidation [149] and release in brain [150,151]