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How alcohol contributes to vitamin E deficiency Increases lipid peroxidation, rapidly consuming vitamin E reserves Impairs absorption and transport of fat-soluble vitamins Common symptoms and clinical consequences of vitamin E deficiency Increased inflammatory burden Muscle weakness or coordination changes Peripheral neuropathy in more advanced deficiency Reduced immune resilience (31) Clinically, vitamin E deficiency often shows up as accelerated wear and tearpatients experience heightened inflammation, slower recovery, and increased sensitivity to physical or neurological stress

2007;292:R2144-2150

FOXO4, one of the members of this family, interacts with the p53 protein to help senescent cells avoid apoptosis