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Isatuximab interacts with a discontinuous epitope partially overlapping the catalytic site, whereas Daratumumab binds to two continuous amino acid sequences situated outside the enzymatic active site of CD38 (52, 53)

(PubMed) Bertoia M, Albanes D, Mayne ST, Mannisto S, Virtamo J, Wright ME

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Acetaldehyde buildup is responsible for many of the unpleasant effects of overindulging, including the dreaded morning-after hangover
