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SAM stops being drained by the methylation step, so methyl-group supply recovers

Intravenous glutathione achieves higher tissue levels but requires medical administration and carries infection and interaction risks

Mol Plant Pathol 14(4):429438 Gambino G, Gribaudo I (2012) Genetic transformation of fruit trees: current status and remaining challenges

This is of potential consequence when drug discontinuation is required or when drugs are prescribed that might interact with fluoxetine and norfluoxetine following the discontinuation of fluoxetine [see Clinical Pharmacology (12.3)]

Then there's the degradation of the target compound

The liposomal delivery format, which encapsulates glutathione in phospholipid vesicles, appeared to protect the tripeptide from digestive degradation and enhance absorption significantly