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Moreover, inhibiting fumarate hydratase, a critical enzyme of the citric acid cycle (CAC), reduces the long-term repopulating potential of HSCs (15)

The most significant pathogenic finding in the brains of PD patients is the progressive loss of dopaminergic neurons in the basal complexes
doi: 10.1146/annurev-pharmtox-011112-140320

Clinical studies show significant correlations between CSF levels of HMGB1/IL-1 and SN necrosis in PD patients, confirming neuroinflammatory synergy with necrosis [188]
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