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Aldini G, Altomare A, Baron G, Vistoli G, Carini M, Borsani L, Sergio F

These processes do not only depend on intracellular dynamics of hepatocytes, but are in part regulated by intercellular signaling between hepatocytes and immune cells such as the livers resident Kupffer cells (KCs) and recruited monocyte-derived macrophages (ms) 14

standalone not FDA-approved

Pathway / Mechanistic Context Mechanistic discussions in preclinical publications describe Dihexa in relation to the hepatocyte growth factor (HGF) / c-Met receptor system, a receptor tyrosine kinase complex associated with intracellular signaling cascades such as PI3K/AKT and MAPK-related pathways

Pacurari M, Kafoury R, Tchounwou PB, Ndebele K

Please refer to the online application posting for XENOVIEW TM available at , for additional detail describing the technology and the diseases diagnosed by the technology