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Mitochondrial glutathione neutralizes these free radicals before they damage mitochondrial DNA and membranes

As a result, GSH supplementation in the long run may prove to be an effective means of reducing levels of chronic oxidative stress and its related disorders and diseases

Preclinical studies and clinical trials suggest that antioxidants, such as small thiol molecules (N-acetyl-L-cysteine and carbocysteine), antioxidant enzymes (glutathione peroxidases), activators of Nrf2-regulated antioxidant defense system (sulforaphane), and vitamins, for example, C, E, and D, enhance the endogenous antioxidant system and reduce oxidative stress

Trends Immunol 2009

However, there are notable biocompatibility concerns associated with Ni 2+ ions and nano/micron-sized alloy particles from these metal implants

Resonances from the glutamate moiety are located at 2.15, 2.55 and 3.77 ppm, from the cysteine part at 2.93, 2.98 and 4.56 ppm, and the glycine moiety contributing to the 3.77 ppm peak (Harris et al., 2017)