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FOXO4-DRI mainly kills senescent cells because these cells depend on a specific FOXO4-p53 connection to stay alive

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As a result, increased phagocytic capacity of microglia and infiltrating macrophages, allowing for enhanced clearance of inhibitory myelin debris, would be a promising therapeutic strategy in MS

A novel HDAC/MIF dual-target inhibitor (6a) at a concentration of 12.5 M promotes apoptosis by inhibiting HDAC activity and inducing histone acetylation (H3K27ac), while simultaneously blocking the MIF-CXCR7-AKT signaling pathway, thereby synergistically inhibiting the survival and proliferation of NSCLC cells (especially EGFR-mutant/TKI-resistant strains)

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