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Description
Knockout of PDCE2 by CRISPR and expression of FLAG-tagged PDCE2 in THP-1 cells demonstrated that LPS-induced glutathionylation is associated with wild type PDCE2 but not mutant protein lacking the lipoamide-linking lysine residues

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However, the hypercoagulable state, as well as the molecular mechanism of this aspect of the pathogenesis of -thalassemia/HbE, remains poorly understood

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