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The serum IGFBP-3 concentration is also useful in the diagnosis of GH deficiency in children and is less age dependent and more sensitive (96%) and more specific (97%) than IGF-1

This substitution results in an alanine-to-valine change, leading to a significant reduction in the enzyme activity observed in vitro in both heterozygotes and homozygotes [67,108]

[DOI] [PubMed] [Google Scholar] Baird L

[DOI] [PubMed] [Google Scholar] 10.Wu J., Liu Q., Zhang X., Wu X., Zhao Y., Ren J

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