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Although the exact host receptor for TMAO has not been identified, studies have shown that TMAO influences cholesterol, sterol, and bile acid metabolism in the liver

Ural, C., et al., Alpha-lipoic acid alleviates colistin nephrotoxicity in rats

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Treatment of HAECs and HVSMCs with TMAO, as well as acute TMAO injection in mice, activates NF-B signaling, leading to leukocyte recruitment to the aortic endothelium [38]

doi: 10.1111/j.1526-4610.2006.00454.x 92
