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Mice fed a normal diet with a large AGE content show higher levels of AGEs (pentosidine, carboxymethyllysine, methylglyoxal-derived hydroimidazolone) in both Achilles and tail tendons (with the Achilles having higher levels than the tail tendons) compared to mice fed a high-fat low-AGE content diet (Skovgaard et al ., 2017)

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The hyperphosphorylation of tau occurs to a stoichiometry at least three-fold greater than normal tau, contributing to the aggregation of paired helical filaments