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Consistent with these in vivo effects, we found that bradykinin-stimulated production of NO was enhanced by vector-mediated GPx1 overexpression in cultured endothelial cells at baseline and in the presence of exogenous homocysteine [60]

Transketolase is encoded by the TKT gene

Compounds that can shift cellular energetics, improve metabolic flexibility, and potentially slow the clock on age-related decline

Elevated ROS levels can lead to oxidative damage of nucleotides in the nucleotide pool and DNA molecules

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