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Understanding the mechanisms that govern the entry into and exit from the DTP statesuch as epigenetic remodeling, metabolic rewiring, and transcriptional plasticityreveals actionable vulnerabilities

In addition, CR6-interacting Factor 1 (CRIF1), also known as growth arrest and DNA damage-inducible proteins-interacting protein 1 (GADD45GIP1), interacts with Neh2 domain and the C-terminal region containing Neh1 and Neh3 of NRF2 to promote NRF2 ubiquitylation and degradation in a redox-independent manner [22]

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Norepinephrine stimulates glycogenolysis in astrocytes to fuel neurons with lactate

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Experimental design Healthy and diseased free Laca mice of either sex (34 months old, weighing 2530 g) were procured from the Central Animal House (CAH), Panjab University, and used in the present study