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Increased of LDHA expression is found in paclitaxel-resistant TNBC cells, and LDHA knockdown or the LDH inhibitor oxamate both enables paclitaxel-resistant TNBC cells to be re-sensitized to paclitaxel

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Excess Fe 2+ can donate electrons to H 2 O 2 and O 2 , resulting in substantial production of O 2 and OH free radicals which may cause lipid peroxidation of neuronal membranes as well as accelerated generation of guanidine compounds in the brain, ultimately leading to epileptic conditions (51)

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Hindorff LA, Sethupathy P, Junkins HA, Ramos EM, Mehta JP, Collins FS, et al
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