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When serum ferritin levels elevated, it causes exacerbated inflammatory conditions and induces oxidative damage and ferroptosis, along with the decrease in GSH levels (which functions as an oxidative stress regulator), creating a series of reactions that resulted in multiple organ failure, pulmonary injury, and reduced lung capacity in the study Group A

In a 4-week, open-label pilot study in 23 treatment-seeking cocaine-dependent subjects, NAC at doses of 1.2, 2.4, and 3.6 g/day improved retention rates and was well tolerated [127]

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