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Caloric deficit even a mild 300-500 calorie daily deficit dramatically improves outcomes

In summary, our data provide new insights into the effects of tesofensine on weight loss and the underlying neuronal mechanisms, suggesting that tesofensine may be an effective treatment for obesity and that it may be a valuable adjunct to other appetite suppressants to prevent body weight rebound

Adequate B12 levels can prevent anemia and support a healthy cardiovascular system long-term
