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J Trans Med (2019) 17:213

doi: 10.1038/s41598-024-53836-0, 47

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In particular, some irritating agents, as well as metabolites of the oxidative stress, have proved to be potent activators of the channel TRPA1 on primary sensory nerve fibers which innervate the respiratory tract

Vitamin C helps stabilize and regenerate glutathione, while glutathione enhances the brightening effect of vitamin C

It could be shown that glycolysis in ECs is mainly regulated by PFKFB3 ( in vivo in an EC-specific Pfkfb3 -deficient mouse model, demonstrating that the lack of Pfkfb3 results in decreased branch points and sprouts in a postnatal retina model (Gmez-Escudero et al., 2019), but also in reduced VE-cadherin expression resulting in destabilization of the cellular junctions (Gmez-Escudero et al., 2019)