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Thermal hyperalgesia as a marker of oxaliplatin neurotoxicity: a prospective quantified sensory assessment study

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Perspective, Challenges, and Future Directions Despite the promising roles of glutamine deprivation strategies and supplementation in cancer therapy, several challenges persist, including the need for a comprehensive understanding of the metabolic adaptation of cancer cells, personalized delivery methods, and identifying patient subgroups likely to benefit the most (Figure 3 and Figure 4)

Dosage regimens A drug dosage regimen is a recipe for drug administration, intended to produce the desired therapeutic effect with a minimum of unwanted effects

In the immune microenvironment, glutamate affects the crosstalk between DCs and T cells by acting on different types of glutamate receptors, which we mentioned in the section on glutamate/glutamine earlier