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The combination of repulsion and steric constraints is thought to remove the X-Y linker from near the active site and relieve auto-inhibition

Later the same group showed that PLC plays crucial role in skin inflammation induced by phorbol ester, linking the initial inflammation to the subsequent skin cancer development [23]

A further subject of the present invention consists in pharmaceutical and/or dietetic compositions containing as their active ingredient acetyl L- carnitine, propionyl L-carnitine, or one of their pharmaceutically acceptable salts, in combination with one or more of said drugs useful for the treatment of erectile dysfunction, and at least one pharmaceutically acceptable excipient and/or diluent

doi: 10.3233/JAD-2010-101320

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