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Phase I dose trial suggested that sunitinib plus cisplatin 80 mg/m2 and 5-FU 4,000 mg/m2 were combinable with controllable adverse events (144), and the maximum tolerated dose of sunitinib (MTD) was determined to be 25 mg/day

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36 It is noteworthy that most follow-up assessments in studies involving enamel matrix derivatives were conducted over a period of 1 year, whereas the follow-up duration in our trial was 6 months

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