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Williams' medical team made the announcement on Thursday, sharing that the 59-year-old TV personality received her diagnosis last year after undergoing a "battery of medical tests." Actor Bruce Willis has also been diagnosed with FTD

The disease-associated gene GDAP1 encodes for a mitochondrial outer membrane protein

Systemic administration of therapeutics also results in off-target effects, as only a small fraction of the administered dose crosses the BBB, with the remainder accumulating and affecting peripheral tissues 71,72

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