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Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1- dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4- fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2- azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist

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3.2.3 AMPK AMP-activated protein kinase(AMPK), is a key modulator of energy metabolism in cells

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doi: 10.1126/science.276.5319.1699

Glossary ACSL4 acyl-CoA synthase long-chain family member 4 AGEs advanced glycation end products AGR accessory gene regulator AGR1 accessory gene regulator 1 Akt3 RAC-gamma serine/threonine-protein kinase AL-4 angiopoietin-like factor 4 ANGPTL4 angiopoietin-like factor 4 ATF-3 activating transcription factor 3 CD36 cluster of differentiation 36 CRISPR the clustered regularly interspaced short palindromic repeats DFU diabetic foot ulcer DMT1 divalent metal transporter 1 ECM extracellular matrix EGF epidermal growth factor eNOS endothelial nitric oxide synthase ERK1 extracellular signal-regulated protein kinases 1 FBXL5 F-box and leucine-rich repeat protein 5 GATA2 GATA binding protein 2 GPX glutathione peroxidase GPX4 glutathione peroxidase 4 GSSG glutathione disulfide HO-1 heme oxygenase-1 HSP 32 heat shock protein-32 HSPB1 heat shock protein family B member 1 IGF-1 insulin-like growth factor-1 IL-6 interleukin 6 IL-10 interleukin-10 iNOS inducible nitric oxide synthase IRES internal ribosomal entry sites IRP2 iron regulatory protein 2 JAK/STAT3 the Janus kinase-signal transducer and activator of transcription 3 LC-MS/MS liquid chromatography tandem-mass spectrometry LOX lysyl oxidase LPCTA3 lysophosphatidylcholine acyltransferase 3 MiRNA or MiR micro RNA MMP-9 matrix metalloproteinase 9 NADPH nicotinamide adenine dinucleotide phosphate NF-kappa B nuclear factor kappa B NF-KB19 nuclear transcription factor 19 NLRP3 the NACHT, LRR, and PYD domains-containing protein 3 NRF2 nuclear factor erythroid 2-related factor 2 OSI oxidative stress index PDGF platelet-derived growth factor PKB protein kinase B PUFAs polyunsaturated fatty acids RCS reactive carbonyl species RIPK1/RIPK3 receptor-interacting protein kinase 1/receptor-interacing protein kinase 3 ROS reactive oxygen species SF ferritin SLC7A11 the glutamate/cystine antiporter solute carrier family 7 member 11 STZ streptozotocin system X C cystine-glutamate transporters TGF- transforming growth factor-beta TNF- necrosis factor alpha TS transferrin saturation VEGF vascular endothelial growth factor VEGFR-1 vascular endothelial growth factor receptor 1 VEGFR2 vascular endothelial growth factor receptor 2 4-HNE 4-Hydroxy-2-nonenal References 1 Al-MohaithefM.AbdelmohsenS